Why choose the Prequel® test?

The accuracy of this test is over 99.9%; the fetal fraction is analyzed with the latest 4.0 technology.

It is complete. Over 100 microdeletions and duplications.

It is safe, with no risk to the health of the mother and the baby.

You will not be alone. This test is performed under the advice of a team of experts.

It is fast. The results are obtained in 3-5 working days from the moment the sample is received by the laboratory.

It is convenient. It can be performed in the case of twin pregnancies and IVF.

The PoliGenetics team is composed of highly qualified doctors and scientists, including specialists in human genetics, laboratory medicine, obstetrics and gynecology.

Our PoliGenetics team is happy to answer all your questions regarding prenatal diagnosis, NIPT and the interpretation of the Prequel test.

In 99.4% of cases, the Prequel® test provides a result on genetic syndromes.

The probability that the Prequel® test can be performed successfully depends greatly on the amount of cell-free fetal DNA present in the mother's blood. The percentage of cffDNA also depends on the duration of the pregnancy (the earlier the pregnancy, the lower the percentage of cffDNA), as well as on the mother's weight (the higher the mother's weight, the less cffDNA from the baby will be isolated).

To determine a specific chromosomal disorder in the fetus, the amount of cell-free fetal DNA (“fetal fraction”) must be at least 2% in the mother's blood. The Prequel® test can be performed from the 10th week of pregnancy (SG 10 + 0), since the amount of fetal DNA in the mother's blood increases as the pregnancy progresses. By week 21 of pregnancy, the amount of your baby's DNA increases by 0.1% from week to week, and after week 21, the amount increases by 1.1%.

The partner lab measures the "fetal fraction" with each Prequel® test. If the fetal fraction is less than 2%, the test cannot be evaluated. PoliGenetics Lab is then notified by the partner lab that a new blood sample needs to be sent at a later date and informs the customer.